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On 19 February 2025, the Global Cities Hub (GCH) had the honour of opening a high-level Mayor’s Panel at the 4th WHO Global Ministerial Road Safety Conference, alongside city leaders from Paris, New York, Marrakech, and Guayaquil. With over 100 ministers from around the world in attendance and UN high-level officials like Dr Tedros Adhanom Ghebreyesus (WHO Director General), Jean Todt (UN Special Envoy for Road Safety) and Tatiana Molcean (UNECE Executive Secretary), it was remarkable to see an international conference dedicate one of its plenary sessions specifically to cities and mayors—a testament to their central role in shaping global policy.